H-Y antigen in familial XX true hermaphroditism

45,X/47,XXX/47,XX, del(Y)(p?)/46,XX mosaicism causing true hermaphroditism.

Sex differentiation in humans depends on the presence of the Y-linked gene SRY, which is activated in the pre-Sertoli cells of the developing gonadal primordium to trigger testicular differentiation. Occasionally testicular formation can take place in subjects lacking a Y chromosome resulting in a 46,XX sex reversal condition. True hermaphroditism (TH) is a rare form of intersexuality character...

Child with True Hermaphroditism

True hermaphrodites possess both ovarian and testicular tissues which may be present in separate gonads or combined in an ovotestis. External and internal genitalia are ambiguous and variable, though a prominent penial structure is usual. Chromosome examination of true hermaphroditism has revealed an XX sex chromosome complement in the majority of cases, but the XY complement and different mosa...

Evidence of XX-XY sex chromosome mosaicism in a child with true hermaphroditism.

XX true hermaphroditism in southern African blacks: an enigma of primary sexual differentiation.

A high incidence of 46,XX true hermaphroditism exists among southern African blacks. The gonadal distribution and clinical presentation of 38 patients are described. The aim of our study on 11 families with histologically proven XX true hermaphroditism was to determine whether a common genetic or environmental etiology could be identified. Pedigree analysis excluded the presence of a simple inh...

True Hermaphroditism in Chimaeric Mice.